Jerrold R. Turner, MD, PhD Jerrold Turner, MD, PhD
Epithelial Barriers: Structure, regulation, and impact on human health

Professor and Associate Chair, Department of Pathology/MPMM
Committee on Molecular Medicine/MPMM Committee on Cell Physiology

B.A., M.A. Washington University, St. Louis, 1984
Ph.D. Case Western Reserve University, Cleveland, 1990
M.D. Case Western Reserve University, Cleveland, 1991

 

Research Summary

Our interests are focused on how epithelia establish, maintain, and regulate barriers. This fundamental property is essential for survival of multicellular organisms and allows controlled interactions with the external environment and compartmentalization of distinct tissues. The structure that maintains these barriers and regulates flux between cells is the tight junction. The primary goal of our laboratory is to understand the biology of the tight junction.

We take a multidisciplinary approach that integrates cell biology, transport physiology, electrophysiology, structural biology, molecular biology, and mucosal immunology to define fundamentals of structure and function; understand mechanisms of regulation in vitro and in vivo models; determine the contributions of barrier dysfunction to gastrointestinal disease; understand the role of the epithelial barrier in regulating other mucosal processes, e.g. immune responses; and develop novel means to correct barrier function and restore health.

Recent reviews

Shen L, Weber CR, Raleigh DR, Yu D, Turner JR. 2010. Tight junction pore and leak pathways: A dynamic duo. Annu Rev Physiol 2011. (PubMed)

Marchiando AM, Graham WV, Turner JR. Epithelial barriers in homeostasis and disease. Annu Rev Pathol 2010;5:119-44. (PubMed)

Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 2009;9:799-809. (PubMed)

 

 
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