Research Summary

The Kron laboratory is a diverse and collaborative group of cell biologists, geneticists, biochemists, chemists and computer scientists. Our current basic research and technology efforts include 1) defining roles for chromatin dynamics and cell cycle regulation in DNA damage checkpoint response and cellular senescence, 2) dissecting cross-talk between metabolism and DNA damage response, 3) developing novel molecular assays to interrogate cell signaling in cancer, and 4) implementing novel mass spectrometry approaches to enable quantitative proteomics. We also pursue translational projects directed at 1) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization, 2) examining DNA damage and repair in tissues and tumors, and 3) exploiting DNA damage responses to induce anti-tumor immune responses.

Attention: Post-doc inquiries welcomed. Please, contact Dr. Kron at

Selected Publications

J.E. Sylvester, T.S. Bray and S.J. Kron, "Annotator: Post-processing software for generating function-based signatures from quantitative mass spectrometry," J. Proteome Res. 2012 Feb 3. [Epub ahead of print] (PubMed)

Y. Meng, E.V. Efimova, K.W. Hamzeh, T.E. Darga, H.J. Mauceri, Y.-X. Fu, S.J. Kron and R.R. Weichselbaum, "Radiation-inducible immunotherapy for cancer: Senescent tumor cells as a cancer vaccine," Mol Ther. 2012 Feb 14. doi: 10.1038/mt.2012.19. [Epub ahead of print] (PubMed)

E. Labay, E.V. Efimova, B.K. Quarshie, D.W. Golden, R.R. Weichselbaum, and S.J. Kron, "Ionizing Radiation Induced Foci (IRIF) persistence screen to discover enhancers of accelerated senescence," Int. J. High Throughput Screening, 2011(2):1-13, 201. (Dovepress)

O.A. Ulanovskaya, J. Cui, S.J. Kron and S.A. Kozmin, "A pairwise chemical genetic screen identifies new inhibitors of glucose transport," Chemistry & Biology, 18:222-30, 2011.
(PubMed)

G. Zhou, J.E. Sylvester, D. Wu, D.R. Veach and S.J. Kron, "A magnetic bead-based protein kinase assay with dual detection techniques," Anal. Biochem., 408:5-11, 2011 (PubMed)

D. Rosetto, A.W. Truman, S.J. Kron and J. Côté, "Epigenetic modifications in double-strand break DNA damage signaling and repair," Clin. Cancer Res., 16:4543-52, 2010 (Clin. Cancer Research)

K. Kristjansdottir and S.J. Kron, "Stable-isotope labeling for protein quantitation by mass spectrometry," Current Proteomics, 7:144-155, 2010 (Current Proteomics)

G. Zhou, X. Yan, D. Wu and S.J. Kron, "Photocleavable peptide-conjugated magnetic beads for protein kinase assays by MALDI-TOF MS," Bioconj. Chem., 21:1917-24, 2010 (PubMed)

M.R. Mand, D. Wu, D.R. Veach and S.J. Kron, "Cell treatment and lysis in 96 well filter-bottom plates for screening Bcr-Abl activity and inhibition in whole cell extracts," J. Biomol. Screening, 15:434-40, 2010 (PubMed)

J.E. Sylvester and S.J. Kron, "A bead-based activity screen for small-molecule inhibitors of signal transduction in chronic myelogenous leukemia cells," Mol. Cancer Ther., 9:1469-81, 2010 (PubMed)

D. Wu, J.E. Sylvester, L.L. Parker, G. Zhou and S.J. Kron, "Peptide reporters of kinase activity in whole cell lysates," Biopolymers: Peptide Science, 94:475-86, 2010 (PubMed)

E.V. Efimova, H.J. Mauceri, D.W. Golden, E. Labay, V.P. Bindokas, T.E. Darga, C. Chakraborty, J.C.B. Andrade, C. Crawley, H.G. Sutton, S.J. Kron and R.R. Weichselbaum, "Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors," Cancer Res., 70:6277-82, 2010 (PubMed)

C.C. Nnakwe, M. Altaf, J. Côté and S.J. Kron, "Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping," DNA Repair, 8(12):1452-61, 2009 (PubMed)

Tobe BT, Kitazono AA, Garcia JS, Gerber RA, Bevis BJ, Choy JS, Chasman D, Kron SJ. (2009) "Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase." Cell Div., 4:12. (PubMed)

S.L. Volchenboum, K. Kristjansdottir, D. Wolfgeher, and S.J. Kron, "Rapid validation of Mascot search results via stable isotope labeling, pair picking, and deconvolution of fragmentation patterns," Mol. Cell. Proteomics, 8:2011-22, 2009 (PubMed)