30400. Protein Fundamentals
A comprehensive survey of protein and DNA structure chromatin,and
DNA binding proteins.
(Autumn: Piccirilli, Koide.)
31000. Fundamentals in Molecular Biology
The course covers nucleic acid structure and DNAtopology, recombinant
DNA technology, DNA replication, DNA damage, mutagenesis and repair,
Transposons and site-specific recombination, prokaryotic and eukaryotic
transcription and its regulation, RNA structure, splicing and catalytic
RNAs, protein synthesis, and chromatin.
(Winter: Storb, Staley.)
31200. Molecular Biology I
Nucleic acid structure; mechanisms of transcription and replication.
Regulation of transcription in prokaryotes, and of DNA replication
in prokaryotes and eukaryotes.
31300. Molecular Biology II
Eukaryotic Gene Expression. Transcription and Posttranscriptional
Regulation. Analysis of regulatory pathways and mechanisms involved
in the control of eukaryotic gene activity.
(Spring: Singh, Staley.)
31400. Genetic Analysis of Model Organisms
Coverage of the fundamental tools of genetic analysis as used to
study biological phenomena. Topics include genetic exchange in prokaryotes
and eukaryotes, analysis of gene function, and epigenetics.
(Autumn: Bishop and Staff.)
31500. Genetic Mechanisms
Advanced coverage of genetic mechanisms involved in genome stability
and rearrangement in lower and higher organisms. Topics include
the genetics of mutagenesis, DNA repair, homologous and site specific
recombination, transposition and chromosome segregation.
(Winter: Bishop, Ellis.)
31600. Cell Biology
Eukaryotic protein traffic and related topics, including molecular
motors and cytoskeletal dynamics, organelle architecture and biogenesis,
protein translocationand sorting, compartmentalization in the secretory
pathway, endocytosis and exocytosis,and mechanisms and regulation
of membrane fusion.
(Autumn: Turkewitz, Glick.)
31700. Cell Biology II
Cell cycle progression, cell growth, cell death, cytoskeletal polymers
and motors, cell motility, and cell polarity.
(Winter: Glotzer, Kovar)
31900. Introduction to Research
Lectures on current research by departmental faculty and other invited
speakers. A required course for all first-year graduate students.
(Autumn, Winter: Staff.)
34300. Principles and Practices of Electron
This course deals with the principles involved in obtaining electron
micrographs of biological specimens. Preparation techniques and
analytical procedures will be offered at an individualized level.
34600. Viruses of Eukaryotes
An advanced lecture course on viruses infecting animals and humans.
35400. Advanced Developmental Biology
This course provides an overview of the fundamental questions of
developmental biology, presenting both the classical embryological
experiments that defined these questions, and the modern molecular
and genetic experiments that have been employed to try to reach
mechanistic answers to these questions. The first portion of the
course will focus on the mechanism of axis formation in a variety
of organisms; the second part of the course will explore selected
topics in the field.
(Autumn: Ferguson, Preuss.)
35500. Developmental Genetics of Non-vertebrate
This course explores the use of genetics in three different model
systems, C. elegans, Drosophila melanogaster and Arabodopsis thaliana,
to elucidate developmental mechanisms. The class will focus on a
series of interrelated topics: for each topic, introductory material
presented by the lecturer will be followed by student-led discussions
of individual papers.
(Winter: Ferguson, Du, Greenberg.)
35600. Vertebrate Developmental Genetics
This advanced-level course combines lectures, student presentations,
and discussion sections. It covers major topics in the developmental
biology of vertebrate embryos (e.g., formation of the germ line,
gastrulation, segmentation, nervous system development, limb patterning,
organogenesis). The course makes extensive use of the current primary
literature and emphasizes experimental approaches including embryology,
genetics, and molecular genetics.
(Spring: Prince, Millen.)
35700. Developmental Genetics and Evolution
This course uses the developmental genetics of established invertebrate
and vertebrate model systems as an entry point to explore the developmental
basis of evolutionary change. Topics range from the evolution of
gene regulation to the origin of novelties such as eyes and wings.
We will study original research papers. The purpose of this course
is to provide graduate students (and advanced undergraduates) with
a developmental genetic perspective on evolutionary questions that
have emerged in various disciplines including developmental biology,
paleontology and phylogenetic systematics.
35800. Developmental Neurobiology
Topics include neural induction, early patterning of the central
nervous system, axon guidance and neuronal migration, the development
of brain activity, and the mechanisms of plasticity that fine-tune
brain function. Approaches will range from molecular to cellular
to systems neurobiology. Focus will be on the vertebrate CNS but
attention will be given to important lessons from invertebrate systems.
(Winter: Grove, Zou, Issa.)
38000. Genomic & Proteomic Approaches
to Biological Questions
Lectures with emphasis on concepts and experimental approaches in
Genomics and Proteomics. Topics to include: Bioinformatic tools
for DNA analysis and protein analysis, genomic tools for high-throughput
genetics, arrays for DNA & RNA detection, genome organization,
comparative genomics, human evolution, current technologies for
profiling proteomes, protein interaction networks, chemical genomics,
and markers of disease.
(Spring: Preuss, Kay.)
39900. Readings/Topics in MGCB.
47000. Thesis Research.
47100. Non-Thesis Research.